{"id":5323,"date":"2021-02-05T16:57:00","date_gmt":"2021-02-05T16:57:00","guid":{"rendered":"https:\/\/cnl.wpengine.com\/?page_id=5323"},"modified":"2021-11-16T11:48:06","modified_gmt":"2021-11-16T16:48:06","slug":"low-dose-radiation-research","status":"publish","type":"page","link":"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/","title":{"rendered":"Low Dose Radiation Research"},"content":{"rendered":"<div class=\"wpb-content-wrapper\"><p>[vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; css=&#8221;.vc_custom_1622396940267{padding-bottom: 100px !important;}&#8221; z_index=&#8221;&#8221;][vc_column][vc_column_text]<\/p>\n<h2 class=\"h3\">Extending the life of stem cells<\/h2>\n<p>[\/vc_column_text][vc_row_inner row_type=&#8221;row&#8221; type=&#8221;full_width&#8221; text_align=&#8221;left&#8221; css_animation=&#8221;&#8221;][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text]The development of stem cell-based therapy relies on the availability of adequate supply of healthy donor-derived stem cells. Unfortunately, stem cell therapy faces a major challenge, which is that these cells suffer from premature aging and decreased functional and regenerative capacity when they are removed from the body.<\/p>\n<p>Building on earlier CNL research which suggested that low-dose radiation could have a positive impact on stem cell performance, the Radiobiology team undertook a study to investigate the effects of low-dose radiation exposure on mesenchymal stem and progenitor cells, and endothelial colony forming cells. In the study, these cells were irradiated with varying levels of radiation, and aged in culture in a controlled manner, allowing us to monitor cell proliferation and functional changes.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text]The results show significant potential for the use of low-dose radiation to improve stem cell therapy. While non- irradiated stem cells aged significantly, cells treated with low-dose radiation demonstrated improved proliferation, mobility and chondogrenic differentiation capacity. Overall, these results provide the first evidence of delayed aging and improved functional properties of these specific stem cells.<\/p>\n<p>CNL is now undertaking further studies to better understand the mechanisms behind the performance improvements.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; z_index=&#8221;&#8221; background_color=&#8221;#1e73be&#8221;][vc_column]<div class='testimonials_c_holder clearfix dark'><ul class=\"slides\"><li id=\"testimonials-c-5326\" class=\"testimonial_content\"><div class=\"testimonial_content_inner\"><div class=\"testimonial_text_holder\"><div class=\"testimonial_text_inner\" style=\"\"><p>CNL\u2019s research is the first to suggest that low dose radiation can improve the efficacy of immune checkpoint therapy, which improves a new form of cancer therapy that\u2019s already proven to be effective. CNL recently filed a provisional patent on combining these two therapies for the treatment of a specific cancer.<\/p><p class=\"testimonial_author\" style=\"\"><\/p><\/div><\/div><\/div><\/li><\/ul><\/div>[\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; css=&#8221;.vc_custom_1590885217309{padding-top: 100px !important;padding-bottom: 100px !important;}&#8221; z_index=&#8221;&#8221;][vc_column][vc_column_text]<\/p>\n<h2 class=\"h3\">Improving the effectiveness of cancer treatments<\/h2>\n<p>[\/vc_column_text][vc_row_inner row_type=&#8221;row&#8221; type=&#8221;full_width&#8221; text_align=&#8221;left&#8221; css_animation=&#8221;&#8221;][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text]While exposure to high doses of radiation is clearly dangerous to human beings, there is growing evidence that low doses of ionizing radiation may \u2013 surprisingly \u2013 be beneficial for people. This experience actually stimulates the activation of repair mechanisms that have long lasting impacts which help protect people against disease. Our studies have shown that low doses don\u2019t pose a threat to humans. Instead, this form of radiation improves your body\u2019s ability to heal itself by boosting your immune system.<\/p>\n<p>Over the years, CNL has conducted studies that show significant improvements from exposure to low dose radiation, particularly with older specimens whose immune systems look much younger following the treatment. These results made us wonder whether we could apply this technique to medical therapies such as cancer treatment. More specifically, CNL considered the use of low dose radiation to supplement an existing form of cancer treatment, known as immune checkpoint therapy.[\/vc_column_text][\/vc_column_inner][vc_column_inner width=&#8221;1\/2&#8243;][vc_column_text]In simple terms, this type of therapy removes the \u2018brakes\u2019 from a person\u2019s immune system. Normally, our immune system can differentiate normal cells from foreign cells by molecules known as \u201ccheckpoints\u201d, which restrain the immune system when present on a cell. Unfortunately, cancer cells have the ability to conceal themselves from the immune system through the use of these checkpoints. By deactivating these brakes, we can boost our immune response against cancer cells. This therapy has already revolutionized the field, showing a great deal of promise in treating certain cancers.<\/p>\n<p>CNL\u2019s research is the first to suggest that low dose radiation can improve the efficacy of immune checkpoint therapy, which improves a new form of cancer therapy that\u2019s already proven to be effective. CNL recently filed a provisional patent on combining these two therapies for the treatment of colon cancer.[\/vc_column_text][\/vc_column_inner][\/vc_row_inner][\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; css=&#8221;.vc_custom_1591193513237{background-image: url(https:\/\/www.cnl.ca\/wp-content\/uploads\/2020\/06\/waves-bg-title.png?id=329) !important;background-position: center !important;background-repeat: no-repeat !important;background-size: contain !important;}&#8221; z_index=&#8221;&#8221; el_class=&#8221;bg-right-top&#8221;][vc_column offset=&#8221;vc_col-lg-5 vc_col-md-6&#8243; css=&#8221;.vc_custom_1592926434293{padding-bottom: 30px !important;}&#8221;][vc_column_text css=&#8221;.vc_custom_1622396980778{padding-bottom: 21px !important;}&#8221;]<\/p>\n<h2 class=\"h1\">A Fountain of Youth?<\/h2>\n<p>[\/vc_column_text][vc_column_text css=&#8221;.vc_custom_1612550221415{padding-bottom: 30px !important;}&#8221;]Patent pending on stem cell therapies to treat muscle disease and aging[\/vc_column_text][vc_column_text]Researchers in CNL\u2019s Radiobiology and Health department demonstrated some very compelling results treating stem cells with low dose radiation that could lead to new treatments for muscle diseases and aging. Staff in CNL\u2019s Radiobiology group theorized that the exposure of low levels of radiation to muscle stem cells may have therapeutic applications.<\/p>\n<p>CNL found that low dose radiation exposure resulted in a substantial improvement of muscle fiber formation, and that the loss of this capacity \u2013 which is routinely observed in a long term culture \u2013 is partially reversed through this treatment. Overall, the data indicates that low dose radiation enhances muscle stem cell memory. Although specific mechanisms of this enhancement are unknown, these results open up opportunities for improving the properties of muscle stem cells destined for therapeutic transplantation.[\/vc_column_text][\/vc_column][vc_column offset=&#8221;vc_col-lg-7 vc_col-md-6&#8243;]<div class=\"qode_video_box\">\r\n\t<a itemprop=\"image\" class=\"qode_video_image\" href=\"https:\/\/www.youtube.com\/watch?v=uMzL38ww4BU&#038;feature=emb_logo\" aria-expanded=\"false\">\r\n\t\t\t\r\n\t\t\t<img decoding=\"async\" src=\"https:\/\/www.cnl.ca\/wp-content\/uploads\/2020\/09\/Biology_Lab-5.jpg\" alt=\"\" \/>\r\n\t\t\t<span class=\"qode_video_box_button_holder\" aria-hidden=\"true\">\r\n\t\t\t\t<span class=\"qode_video_box_button\">\r\n\t\t\t\t\t<span class=\"qode_video_box_button_arrow\">\r\n\t\t\t\t\t<\/span>\r\n\t\t\t\t<\/span>\r\n\t\t\t<\/span>\r\n\t\t\t<\/a>\r\n    \r\n    <div class=\"iframe-container\" aria-hidden=\"true\">\r\n       \r\n        \r\n            <div class=\"iframe-container_inner\">\r\n            <iframe loading=\"lazy\" title=\"Loading Video\" src=\"\" allowfullscreen=\"\" width=\"560\" height=\"315\" frameborder=\"0\"><\/iframe><a href=\"#\" class=\"close-video\" ><i class=\"fa fa-close\"><\/i> <span class=\"screen-reader-text\"> Close Video <\/span><\/a>\r\n            <\/div>\r\n        \r\n        \r\n    <\/div>\r\n   \r\n    \r\n      \r\n    <div class=\"video_contant\">\r\n     \t\t              \r\n    <\/div>\r\n    \r\n    \r\n    \r\n    \r\n<\/div>[\/vc_column][\/vc_row][vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;center&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; css=&#8221;.vc_custom_1611689671039{padding-top: 90px !important;padding-bottom: 120px !important;background-color: #f5f5f5 !important;}&#8221; z_index=&#8221;&#8221; background_color=&#8221;#efefef&#8221; background_image=&#8221;5228&#8243;][vc_column][vc_empty_space][vc_single_image image=&#8221;97&#8243; img_size=&#8221;full&#8221; alignment=&#8221;center&#8221; qode_css_animation=&#8221;&#8221;][vc_column_text css=&#8221;.vc_custom_1637081258616{padding-top: 30px !important;padding-bottom: 38px !important;}&#8221;]<\/p>\n<h3>Meet our talented health sciences team!<\/h3>\n<p>[\/vc_column_text][vc_empty_space]<a  itemprop=\"url\" href=\"https:\/\/www.cnl.ca\/health-science-2\/meet-the-team-health-sciences\/\" target=\"_self\"  class=\"qbutton  default\" style=\"\">Click here.<\/a>[vc_empty_space height=&#8221;64px&#8221;][\/vc_column][\/vc_row]<\/p>\n<\/div>","protected":false},"excerpt":{"rendered":"<p>[vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; css=&#8221;.vc_custom_1622396940267{padding-bottom: 100px !important;}&#8221; z_index=&#8221;&#8221;][vc_column][vc_column_text] Extending the life of stem cells [\/vc_column_text][vc_row_inner row_type=&#8221;row&#8221;&#8230;<\/p>\n","protected":false},"author":3,"featured_media":0,"parent":1460,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"inline_featured_image":false,"episode_type":"","audio_file":"","cover_image":"","cover_image_id":"","duration":"","filesize":"","date_recorded":"","explicit":"","block":"","itunes_episode_number":"","itunes_title":"","itunes_season_number":"","itunes_episode_type":"","filesize_raw":"","footnotes":""},"class_list":["post-5323","page","type-page","status-publish","hentry"],"acf":[],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v26.3 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Low Dose Radiation Research - Canadian Nuclear Laboratories<\/title>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" href=\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/\" \/>\n<meta property=\"og:locale\" content=\"en_US\" \/>\n<meta property=\"og:type\" content=\"article\" \/>\n<meta property=\"og:title\" content=\"Low Dose Radiation Research - Canadian Nuclear Laboratories\" \/>\n<meta property=\"og:description\" content=\"[vc_row css_animation=&#8221;&#8221; row_type=&#8221;row&#8221; use_row_as_full_screen_section=&#8221;no&#8221; type=&#8221;grid&#8221; angled_section=&#8221;no&#8221; text_align=&#8221;left&#8221; background_image_as_pattern=&#8221;without_pattern&#8221; css=&#8221;.vc_custom_1622396940267{padding-bottom: 100px !important;}&#8221; z_index=&#8221;&#8221;][vc_column][vc_column_text] Extending the life of stem cells [\/vc_column_text][vc_row_inner row_type=&#8221;row&#8221;...\" \/>\n<meta property=\"og:url\" content=\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/\" \/>\n<meta property=\"og:site_name\" content=\"Canadian Nuclear Laboratories\" \/>\n<meta property=\"article:publisher\" content=\"https:\/\/www.facebook.com\/CanadianNuclearLaboratories\/\" \/>\n<meta property=\"article:modified_time\" content=\"2021-11-16T16:48:06+00:00\" \/>\n<meta name=\"twitter:card\" content=\"summary_large_image\" \/>\n<meta name=\"twitter:site\" content=\"@CNL_LNC\" \/>\n<meta name=\"twitter:label1\" content=\"Est. reading time\" \/>\n\t<meta name=\"twitter:data1\" content=\"4 minutes\" \/>\n<script type=\"application\/ld+json\" class=\"yoast-schema-graph\">{\"@context\":\"https:\/\/schema.org\",\"@graph\":[{\"@type\":\"WebPage\",\"@id\":\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/\",\"url\":\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/\",\"name\":\"Low Dose Radiation Research - Canadian Nuclear Laboratories\",\"isPartOf\":{\"@id\":\"https:\/\/www.cnl.ca\/#website\"},\"datePublished\":\"2021-02-05T16:57:00+00:00\",\"dateModified\":\"2021-11-16T16:48:06+00:00\",\"breadcrumb\":{\"@id\":\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/#breadcrumb\"},\"inLanguage\":\"en-US\",\"potentialAction\":[{\"@type\":\"ReadAction\",\"target\":[\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/\"]}]},{\"@type\":\"BreadcrumbList\",\"@id\":\"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/#breadcrumb\",\"itemListElement\":[{\"@type\":\"ListItem\",\"position\":1,\"name\":\"Home\",\"item\":\"https:\/\/www.cnl.ca\/\"},{\"@type\":\"ListItem\",\"position\":2,\"name\":\"Health Sciences\",\"item\":\"https:\/\/www.cnl.ca\/health-science-2\/\"},{\"@type\":\"ListItem\",\"position\":3,\"name\":\"Low Dose Radiation Research\"}]},{\"@type\":\"WebSite\",\"@id\":\"https:\/\/www.cnl.ca\/#website\",\"url\":\"https:\/\/www.cnl.ca\/\",\"name\":\"Canadian Nuclear Laboratories\",\"description\":\"The science of tomorrow, today.\",\"potentialAction\":[{\"@type\":\"SearchAction\",\"target\":{\"@type\":\"EntryPoint\",\"urlTemplate\":\"https:\/\/www.cnl.ca\/?s={search_term_string}\"},\"query-input\":{\"@type\":\"PropertyValueSpecification\",\"valueRequired\":true,\"valueName\":\"search_term_string\"}}],\"inLanguage\":\"en-US\"}]}<\/script>\n<!-- \/ Yoast SEO plugin. -->","yoast_head_json":{"title":"Low Dose Radiation Research - Canadian Nuclear Laboratories","robots":{"index":"index","follow":"follow","max-snippet":"max-snippet:-1","max-image-preview":"max-image-preview:large","max-video-preview":"max-video-preview:-1"},"canonical":"https:\/\/www.cnl.ca\/health-science-2\/low-dose-radiation-research\/","og_locale":"en_US","og_type":"article","og_title":"Low Dose Radiation Research - Canadian Nuclear Laboratories","og_description":"[vc_row css_animation=&#8221;&#8221; 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